What are some adverse effects of local anesthetic toxicity?

Local anesthetic toxicity can lead to a range of adverse effects that involve both the central nervous system (CNS) and the cardiovascular system. When local anesthetics enter the systemic circulation in significant amounts, they can produce CNS stimulation initially, which may manifest as anxiety, tremors, or seizures. However, as toxicity progresses, CNS depression can occur, leading to symptoms such as drowsiness, respiratory depression, and even loss of consciousness.

In addition to CNS effects, local anesthetic toxicity can have serious cardiovascular implications. These include effects on cardiac conduction, such as bradycardia, arrhythmias, and in severe cases, cardiovascular collapse. The potential for both CNS and cardiovascular effects highlights the importance of monitoring and recognizing signs of toxicity when local anesthetics are used.

Thus, the comprehensive range of effects observed—CNS stimulation, CNS depression, and cardiovascular issues—makes the selected answer the most accurate representation of the adverse effects associated with local anesthetic toxicity.